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Saturday, 12 April 2014

Ebola drug could be ready next year for human testing

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Ebola virus drug could be ready next year for human testing


The Ebola outbreak in West Africa is scary because there are no medications to treat this fatal disease. However, the disease is very rare, there is no incentive for large pharmaceutical companies to develop a treatment.


Ebola virus drug could be ready next year for human testing

However, some small businesses, taking into account of government incentives, engage in the breach. The result: more than half a dozen ideas are actively looking for new drug for ebola.

And these are the days of great help for medication that can treat the virus. Thinking treatments for AIDS and hepatitis C.

Possible treatment for Ebola still many strategies. These include conventional drugs and vaccines, antibodies are suitably designed to not only prevent the spread of diseases in humans, but to be treated in the early stages of infection.

Every idea has shown some promise in animals. But still, nothing surpassed the basic test, so there is nothing ready to deal with in the current outbreak.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, hope the multi-faceted approach, but he said: "I think it's too early to make a prediction about what to do more or less promising."

One of the challenges is that there are several species and strains of the Ebola virus so different, so that it can not be a one size fits all solution.

But an experimental drug might fit the bill. Called BCX4430. Travis Warren at the Institute for Medical Research, U.S. Army Laboratory for Infectious Diseases in Frederick, Maryland, has worked in this antiviral drug.

It has very good against both Ebola and Marburg virus [closely related] when tested in mice. It also protects guinea pigs this virus and yellow fever.

Thus, the next series of tests was dissolved in a small number of monkeys that had been infected by Marburg virus.

It is noteworthy that this drug is developed by a small company called BioCryst Pharmaceuticals.

"Just do not make the cut in a large company," said Dr. William Sheridan, medical director of BioCryst, the pharmaceutical giant Amgen says has been working on.

Ebola, scary as it has only about 2,500 patients since it discovered in 1976, around 1,700 of them to kill. The market for a drug of this type is very low.

However, Sheridan says his company has good reason to pursue his desire to solve one of the biggest health problems.

"There is a market and the market is the U.S. government," he said.

The government is committed to a number of drugs that are effective against Ebola, if someone should try to buy them as a biological agent on the battlefield or an act of terrorism to use . Also help federal agencies to pay for the research, so that the company has been pushing as fast as you can.

"We are currently [Manufacturing] drug experiences and driving safety of the typical animals that you usually do before the drug in humans," says Sheridan. "And once it has been successfully completed, move to the middle of the next, we should have completed the first phase degrees on people."

Phase One tests tell whether the drug is relatively safe, but will not say whether it actually be an effective treatment. Assuming that the drug appears to be safe, it would be ready to be tested in a future outbreak of Ebola.

Of course, the most drug candidates fail to fulfill their original promise , and it is not guaranteed, either.

But Travis Warren army laboratory said that given all the advances in the development of drugs for the treatment of viruses, something will come of this extensive research for Ebola drug.

"I am absolutely certain that it will happen," says Warren. "It's just a matter of time."
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Thursday, 10 April 2014

Can Caffeine slow the progression of Alzheimer's disease?

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Can Caffeine slow the progression of Alzheimer's disease?


Mice genetically altered to aggregation of tau protein and many of the symptoms of Alzheimer's disease, the time was deteriorated progressively have used.

caffeine and selective adenosine receptor antagonists could slow the progression of Alzheimer’s Disease

Caffeine at an early stage to a group of mice, if the symptoms still mild.

Mice were treated with caffeine, showed better storage and less damage and inflammation of the brain as compared to untreated control mice. This means that the caffeine protected mice to an extent. The side effects were moderate.

Perform one of the unexpected results?


Dr. Christa E. Müller: The investigation never knows. We had a hypothesis, but the outcome was uncertain. Fortunately, the hypothesis that caffeine (receptor antagonists and selective adenosine) to slow the progression of Alzheimer's disease in mice a specific model, could be confirmed.

Which doctors and patients should have access to this report?


Dr. Christa E. Müller: For healthy patients with normal caffeine consumption may protect against neurodegenerative diseases. May be the same in the early stages of Alzheimer's disease patients. However, patients who are suffering, for example, due to a serious heart disease such as high blood pressure, be careful and consult your doctor. In addition, pregnant women should avoid caffeine.

Clinical studies should be performed to finally try it in patients.


One of the next steps is to examine a small clinical trial in patients with mild cognitive impairment, whether caffeine prevents or at least delays cause the onset of Alzheimer's disease.

Probably the first studies were conducted with caffeine. However, it would be preferable to use selective antagonists of the adenosine A2A receptor, which are stronger and less side effects.
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Saturday, 29 March 2014

TB infection transmitted from cats to human new case

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Tuberculosis infection spread from cats to humans


The Ministry of Health in the UK discovered the first case of transmission of TB infection from cats to humans. These are the first such case reported. Cat owners should be extremely careful.


The Ministry of Health in the UK discovered the first case of transmission of TB infection from cats to humans

UK Department of Health reported alarming news, they discovered two cases of TB transmission from cat to human. As they say, the TB bacteria was found in nine cats in the areas of Berkshire and Hampshire last year. Reportedly, 39 people have been in contact with animals. Those who have been in contact with animals, received a medical examination. 24 people responded to the offer and two of them were diagnosed with tuberculosis. They immediately began treatment. The infection has also been recognized with two other people, but the disease has not yet been developed, they say.

The analysis of the samples of tuberculosis in humans and infected cats were found to be no different. This shows that the disease actually transmitted from infected cats. As the British Ministry of Health reported that bacteria can be transferred to infect humans through inhalation of contaminated air or touching unprotected animals damaged skin areas.

Tuberculosis is a contagious lung disease that mainly affects the lungs and is often carried out in many chronic complications, which can also lead to death. TB germs can also affect other organs and organ systems. It is one of the three most deadly infectious diseases worldwide (AIDS, tuberculosis, malaria).


TB germs can also affect other organs and organ systems. It is one of the three most deadly infectious diseases worldwide

These are the first documented cases of TB transmission from cat to man and we believe that the probability of such an infection is very low, "said Dilys Morgan, one of the most important scientists of the British Institute of public health. "Tuberculosis is a serious disease, but also with the right treatment curable when treated with long-term use of antibiotics." Treatment takes between six months and one year. After a few weeks of treatment, the person is no longer contagious, but it is important continue to the recommended treatment.

TB is a curable disease, but is far from gone. Nine million people are diagnosed worldwide each year from TB, while three million people die. The difficulty of the fight against tuberculosis is primarily a type of drug-resistant tuberculosis has reported recently. Tuberculosis remains a major problem due to lack of medical care, poor living conditions and poverty in the world.

Risk factors that contribute to facilitate the transfer and susceptibility to TB infection are: Decreased ability of physical defense in general, or by the HIV infection, diabetes, and other serious treatment of lung diseases with certain medications. The ratio of the incidence of tuberculosis has declined over the decades, thanks to better living conditions and hygiene, vaccination against tuberculosis, blockbuster drugs, improved control of milk etc.

Disease prevention is possible with early diagnosis and immediate treatment. Clean and hygienic living environment, adequate nutrition, rest and consolidation of physical forms are the best ways to fight against the infection of tuberculosis TB.
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